Answers to All Your Questions About Covid-19 Vaccines
Exactly 272 days after the World Health Organization declared Covid-19 a global pandemic, 90-year-old Margaret Keenan and 81-year-old William Shakespeare in the United Kingdom became the first two people in the world to receive a thoroughly tested Covid-19 vaccine. (Yes, China and Russia began vaccinating people much earlier, but it’s not clear how well-tested those vaccines are.) In fact, the race for a Covid-19 vaccine began less than two weeks after the world outside China learned of the disease, when the genetic sequence of the SARS-CoV-2 virus was published on January 11.
https://www.reddit.com/r/joshuavpulevstream/
Just a few days after the UK’s vaccinations began, the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) allowing use of an mRNA vaccine made by Pfizer and BioNTech, and continues reviewing the application of another. Four other vaccine candidates are in the U.S. are in phase 3 trials, the final phase before a vaccine is submitted for approval. It’s been a whirlwind, but the next whirlwind is just beginning: actually getting vaccines to the public. The U.S. will need enough doses to vaccinate about 300 million people, estimated Saad Omer, PhD, MBBS, director of the Yale Institute for Global Health, which means 600 million doses if all the vaccines ultimately approved require two doses. As countless public health experts have said throughout the pandemic, vaccines don’t save lives — vaccinations do.
Medium Coronavirus Blog
A Medium blog for Covid-19 news, advice, and commentary.
coronavirus.medium.com
“The coming Covid-19 rollout will mark the first-ever attempt to vaccinate the entire population of the United States,” said Amber Cox, PhD, director of Public Health Epidemiology at Maximus Public Health, a private company that partners with local, state, and federal governments to coordinate and deliver health services. “Moreover, this effort is taking place against the backdrop of deep political, social, and economic divisions that have challenged the public’s trust in the government and in the public health community’s response to Covid-19. A wary public will have questions — lots of them.”
So Elemental has set about answering those questions — lots of them. Keep in mind, however, that many of the answers are unknown or aren’t definitive. Uncertainty is an inherent part of scientific inquiry and the scientific process, just as it’s an unavoidable part of finding our way through a pandemic and vaccinating more people at one time than in our nation’s history.
In fact, public health officials are already trying to prepare folks to expect some level of confusion and change.
“As soon as these things start rolling out, we need to anticipate there’s going to be confusion,” said R. Alta Charo, JD, a professor of law and bioethics at the University of Wisconsin, Madison. “It’s going to be incredibly important there’s a single clear message at the federal level about what steps they are taking and what steps come next. At the state level, officials have to be really open and transparent about why some groups go first and another doesn’t, how they’re making these decisions, and then, crucially, that these are not fixed in stone, that these will change as new vaccines come online, with different profiles for risk and benefit for different groups as we see outbreaks here and there. Change doesn’t mean we were wrong, it means we’re adapting on the fly, as the situation changes, which is what a responsible health department would do.”
The biggest challenges to the Covid-19 vaccine rollout, Cox said, are trust in institutions, perceived safety of the vaccine, real safety of the vaccine, and access to the vaccine. Elemental has attempted to address all four of those issues and more in the answers below.
Throughout the answers, we frequently refer to different phases of trials, so if you’re unfamiliar with the differences, it may help to read this explainer first. In short, phase 1 trials enroll a small number of healthy people to test whether a vaccine appears initially safe and induces an immune response. Phase 2 enrolls more people and looks at safety and dosing. Phase 3 involves tens of thousands of people and looks at safety and the vaccine’s effectiveness against the actual disease. For other vaccine-related terms and acronyms you may not know, there’s a glossary at the end.
